Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Abstract Background Aureobasidium pullulans ( A. ) has a wide range of applications. Ultraviolet (UV) rays from the sun can cause skin photoaging. In order to explore protective effect and application potential lysate on UV-damaged human fibroblasts (HSF) HaCaT Cells, this study investigates anti-aging anti-inflammatory effects as well mechanism anti-oxidative stress at cellular molecular levels through cytotoxicity experiments, enzyme-linked immunosorbent assays (ELISA), real-time quantitative PCR (RT-qPCR). Results The experimental results have shown that effectively reduce loss extracellular matrix components (EMC), such collagen hyaluronic acid (HA). It is also capable scavenging excess reactive oxygen species (ROS) body, thereby increasing activity catalase, decreasing overexpression intracellular metalloproteinases (MMPs), enhancing gene expression metalloproteinase inhibitors (TIMPs), level inflammatory factors, reducing UV-induced apoptosis cells. Meanwhile, oxidative homeostasis regulated Nrf2/Keap1 MAPK signaling pathways. Conclusions This shows resist Graphical